English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

The increasing multidrug resistance in  Helicobacter pylori , also correlated to its biofilm‐forming ability, underlines the need to search novel strategies to improve the eradication rate. Natural compounds are proposed as antibiotic-resistant-breakers capable to restore the efficacy of conventional drugs. Aim of this work was to evaluate the capability of  Pistacia vera  L. oleoresin (ORS) to synergize with levofloxacin (LVX) against resistant  H .  pylori  strains. The antimicrobial activity of  P .  vera  L. ORS and LVX and their combinations was determined by MIC/MBC (in neutral and acidic environments) and checkerboard tests. The anti-biofilm effect was determined by biomass quantification.  In vivo Galleria mellonella  model was used to confirm  in vitro  data.  Pistacia vera  L. ORS and LVX MICs ranged respectively from 780 to 3120 mg/l and from 0.12 to 2.00 mg/l, at pH 7.0 and 5.5. MBCs were similar to MICs.  Pistacia vera  L. ORS was able to synergize with LVX, restoring its effectiveness in LVX resistant strains.  Pistacia vera  L. ORS, LVX and their synergistic combinations displayed significant biofilm reduction.  Pistacia vera  L. ORS and LVX, showed protective effect against  H .  pylori  infection on  G .  mellonella  (62% and 63% of survival, respectively).  Pistacia vera  L. ORS can be considered a promising potentiator to restore the effectiveness of LVX tackling the  H .  pylori  antibiotic resistance phenomenon.

Pistacia vera L. oleoresin and levofloxacin is a synergistic combination against resistant Helicobacter pylori strains