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Candida albicans  is the most frequently isolated fungal species in hospital settings worldwide. However, non-albicans  Candida  species with decreased susceptibility to antifungals have emerged as an important cause of fungemia. The aims of this study were to determine the species distribution of fungi isolated from the blood samples of patients at a Swedish University Hospital and to define the  in vitro  susceptibilities of these isolates to nine antifungal agents. In total, 233 yeast isolates from 143 patients were included in this study. Antifungal susceptibility testing was performed using broth dilution Sensititre YeastOne panels, which comprised amphotericin B, 5-flucytosine, fluconazole, itraconazole, voriconazole, posaconazole, anidulafungin, micafungin, and caspofungin. The most common species in all age groups was  C .  albicans  (n = 93, 65%), followed by  C .  glabrata  (n = 27, 19%) and  C .  parapsilosis  (n = 15, 10%).  C .  glabrata  was mostly found in elderly individuals, while  C .  parapsilosis  was found mainly in young children (p = 0.008). Antifungal resistance was low in the  Candida  species, except for reduced susceptibility to fluconazole among  C .  glabrata  strains.  C .  albicans  is the most frequent colonizer of Swedish patients. In general antifungal resistance is uncommon in  Candida  species. Nevertheless, reduced susceptibilities to fluconazole and echinocandins were found in  C .  glabrata  and  C .  parapsilosis , respectively.

Species distribution and antifungal drug susceptibilities of yeasts isolated from the blood samples of patients with candidemia