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Copper (Cu) deficiency affects iron (Fe) homeostasis in several plant processes, including the increased Fe requirements due to cuproprotein substitutions for the corresponding Fe counterpart. Loss-of-function mutants from  Arabidopsis thaliana  high affinity copper transporter COPT5 and Fe transporters NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 3/4 (NRAMP3 and NRAMP4) were used to study the interaction between metals internal pools. A physiological characterisation showed that the  copt5  mutant is sensitive to Fe deficiency, and that  nramp3nramp4  mutant growth was severely affected under limiting Cu. By a transcriptomic analysis, we observed that  NRAMP4  expression was highly induced in the  copt5  mutant under Cu deficiency, while  COPT5  was overexpressed in the  nramp3nramp4  mutant. As a result, an enhanced mobilisation of the vacuolar Cu or Fe pools, when the other metal export through the tonoplast is impaired in the mutants, has been postulated. However, metals coming from internal pools are not used to accomplish the increased requirements that derive from metalloprotein substitution under metal deficiencies. Instead, the metal concentrations present in aerial parts of the  copt5  and  nramp3nramp4  mutants conversely show compensated levels of these two metals. Together, our data uncover an interconnection between Cu and Fe vacuolar pools, whose aim is to fulfil interorgan metal translocation.

Copper transporter COPT5 participates in the crosstalk between vacuolar copper and iron pools mobilisation