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Filamin-A (FLNA) plays a crucial role in somatostatin receptor (sst) subtype-2 signaling in somatotropinomas. Our objective was to investigate the  in vivo  association between FLNA and sst2 expression, sst5 expression, dopamine receptor subtype-2 (D2) expression, somatostatin receptor ligand (SRL) responsiveness and tumor invasiveness in somatotropinomas. Quantitative real-time PCR was used to evaluate the absolute mRNA copy numbers of  FLNA/sst2/sst5 / D2  in 96 somatotropinomas. FLNA, sst2 and sst5 protein expression levels were also evaluated using immunohistochemistry. The Knosp-Steiner criteria were used to evaluate tumor invasiveness. Median  FLNA ,  sst2 ,  sst5 and D2  copy numbers were 4,244, 731, 156 and 3,989, respectively. Thirty-one of the 35 available tumors (89%) were immune positive for FLNA in the cytoplasm and membrane but not in the nucleus.  FLNA  and  sst5  expression were positively correlated at the mRNA and protein levels (p &lt; 0.001 and p = 0.033, respectively).  FLNA  was positively correlated with  sst2  mRNA in patients who were responsive to SRL (p = 0.014, R = 0.659). No association was found between  FLNA  and tumor invasiveness. Our findings show that in somatotropinomas FLNA expression positively correlated with  in vivo  sst5 and D2 expression. Notably, FLNA was only correlated with sst2 in patients who were controlled with SRL. FLNA was not associated with tumor invasiveness.

Clinical significance of filamin A in patients with acromegaly and its association with somatostatin and dopamine receptor profiles