English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Obesity increases the risk for cardiometabolic diseases.  N -acyl phosphatidylethanolamines (NAPEs) are precursors of  N -acylethanolamides, which are endogenous lipid satiety factors. Incorporating engineered bacteria expressing NAPEs into the gut microbiota retards development of diet induced obesity in wild-type mice. Because NAPEs can also exert anti-inflammatory effects, we hypothesized that administering NAPE-expressing bacteria to low-density lipoprotein receptor ( Ldlr ) −/−  mice fed a Western diet would improve various indices of cardiometabolic disease manifested by these mice. NAPE-expressing  E. coli Nissle 1917  ( pNAPE-EcN ), control  Nissle 1917  ( pEcN ), or vehicle (veh) were given via drinking water to  Ldlr  −/−  mice for 12 weeks. Compared to  pEcN  or  veh  treatment,  pNAPE-EcN  significantly reduced body weight and adiposity, hepatic triglycerides, fatty acid synthesis genes, and increased expression of fatty acid oxidation genes.  pNAPE-EcN  also significantly reduced markers for hepatic inflammation  a nd early signs of fibrotic development. Serum cholesterol was reduced with  pNAPE-EcN , but atherosclerotic lesion size showed only a non-significant trend for reduction. However,  pNAPE-EcN  treatment reduced lesion necrosis by 69% indicating an effect on preventing macrophage inflammatory death. Our results suggest that incorporation of NAPE expressing bacteria into the gut microbiota can potentially serve as an adjuvant therapy to retard development of cardiometabolic disease.

scientific reports

Administration of N-Acyl-Phosphatidylethanolamine Expressing Bacteria to Low Density Lipoprotein Receptor−/− Mice Improves Indices of Cardiometabolic Disease