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Erythritol production is a unique response to hyperosmotic stress that is observed in a small group of yeasts, including  Yarrowia lipolytica . This study investigated whether this unusual mechanism is regulated by the HOG pathway, well described in  Saccharomyces cerevisiae . The gene  YALI0E25135g  was identified as the  Y. lipolytica  homologue of  HOG1  and was found to be phosphorylated in response to hyperosmotic shock. Deletion of the gene caused a significant decrease in resistance to hyperosmotic stress and negatively affected erythritol production. Interestingly, the deletion strain  yl-hog1Δ  displayed significant morphological defects, with the cells growing in a filamentous form. Moreover,  yl-hog1Δ  cells were also resistant to the cell wall damaging agents Congo red and calcofluor white. Collectively, these results indicate that yl-Hog1 is crucial for the cellular response to hyperosmotic stress, plays a role in the induction of erythritol production, and potentially prevents cross-talk with different MAPK signalling pathways in the cell.

Influence of ylHog1 MAPK kinase on Yarrowia lipolytica stress response and erythritol production