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Our study demonstrates that nanoplasmonic sensing (NPS) can be utilized for the determination of the phase transition temperature (T m ) of phospholipids. During the phase transition, the lipid bilayer undergoes a conformational change. Therefore, it is presumed that the T m  of phospholipids can be determined by detecting conformational changes in liposomes. The studied lipids included 1,2-dipalmitoyl- sn -glycero-3-phosphocholine (DPPC), 1,2-dimyristoyl- sn -glycero-3-phosphocholine (DMPC), and 1,2-distearoyl- sn -glycero-3-phosphocholine (DSPC). Liposomes in gel phase are immobilized onto silicon dioxide sensors and the sensor cell temperature is increased until passing the T m  of the lipid. The results show that, when the system temperature approaches the T m , a drop of the NPS signal is observed. The breakpoints in the temperatures are 22.5 °C, 41.0 °C, and 55.5 °C for DMPC, DPPC, and DSPC, respectively. These values are very close to the theoretical T m  values,  i . e ., 24 °C, 41.4 °C, and 55 °C for DMPC, DPPC, and DSPC, respectively. Our studies prove that the NPS methodology is a simple and valuable tool for the determination of the T m  of phospholipids.

Determination of the Main Phase Transition Temperature of Phospholipids by Nanoplasmonic Sensing