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The controlled release of therapeutic inorganic ions from biomaterials is an emerging area of international research. One of the foci for this research is the development of materials, which spatially and temporally modulate therapeutic release, via controlled degradation in the intended physiological environment. Crucially however, our understanding of the release kinetics for such systems remains limited, particularly with respect to the influence of physiological loading. Consequently, this study was designed to investigate the effect of dynamic mechanical loading on a composite material intended to stabilize, reinforce and strengthen vertebral bodies. The composite material contains a borate glass engineered to release strontium as a therapeutic inorganic ion at clinically relevant levels over extended time periods. It was observed that both cyclic (6 MPa 2 Hz) and static (4.3 MPa) compressive loading significantly increased the release of strontium ions in comparison to the static unloaded case. The observed alterations in ion release kinetics suggest that the mechanical loading of the implantation environment should be considered when evaluating the ion release kinetics.

Mechanical loading, an important factor in the evaluation of ion release from bone augmentation materials