English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Runx2 and Sp7 are essential transcription factors for osteoblast differentiation. However, the molecular mechanisms responsible for the proliferation of osteoblast progenitors remain unclear. The early onset of  Runx2  expression caused limb defects through the  Fgfr1 –3 regulation by Runx2. To investigate the physiological role of Runx2 in the regulation of  Fgfr1 – 3 , we compared osteoblast progenitors in  Sp7  −/−  and  Runx2  −/−  mice. Osteoblast progenitors accumulated and actively proliferated in calvariae and mandibles of  Sp7  −/−  but not of  Runx2  −/−  mice, and the number of osteoblast progenitors and their proliferation were dependent on the gene dosage of  Runx2  in  Sp7  −/−  background. The expression of  Fgfr2  and  Fgfr3 , which were responsible for the proliferation of osteoblast progenitors, was severely reduced in  Runx2  −/−  but not in  Sp7  −/−  calvariae. Runx2 directly regulated  Fgfr2  and  Fgfr3 , increased the proliferation of osteoblast progenitors, and augmented the FGF2-induced proliferation. The proliferation of  Sp7  −/−  osteoblast progenitors was enhanced and strongly augmented by FGF2, and  Runx2  knockdown reduced the FGF2-induced proliferation. Fgfr inhibitor AZD4547 abrogated all of the enhanced proliferation. These results indicate that Runx2 is required for the proliferation of osteoblast progenitors and induces proliferation, at least partly, by regulating  Fgfr2  and  Fgfr3  expression.

Runx2 is required for the proliferation of osteoblast progenitors and induces proliferation by regulating Fgfr2 and Fgfr3