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The intracellular environment is a dynamic space filled with variousorganelles moving in all directions. Included in this diverse group oforganelles are vesicles, which are involved in transport of molecular cargothroughout the cell. Vesicles move in either a directed or non-directedfashion, often depending on interactions with cytoskeletal proteins such asmicrotubules, actin filaments, and molecular motors. How these proteins affectthe local fluctuations of vesicles in the cytoplasm is not clear since theyhave the potential to both facilitate and impede movement. Here we show thatvesicle mobility is significantly affected by myosin-II, even though it is nota cargo transport motor. We find that myosin-II activity increases theeffective diffusivity of vesicles and its inhibition facilitates longer statesof non-directed motion. Our study suggests that altering myosin-II activity inthe cytoplasm of cells can modulate the mobility of vesicles, providing apossible mechanism for cells to dynamically tune the cytoplasmic environment inspace and time.

Small-scale displacement fluctuations of vesicles in fibroblasts