English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Long non-coding RNAs (LncRNAs) have emerged as a relevant class of genome regulators involved in a broad range of biological processes and with important roles in tumor initiation and malignant progression. We have previously identified a p53-regulated tumor suppressor signature of LncRNAs ( PR-LncRNAs ) in colorectal cancer. Our aim was to identify the expression and function of this signature in gliomas. We found that the expression of the four  PR-LncRNAs  tested was high in human low-grade glioma samples and diminished with increasing grade of disease, being the lowest in glioblastoma samples. Functional assays demonstrated that  PR-LncRNA  silencing increased glioma cell proliferation and oncosphere formation. Mechanistically, we found an inverse correlation between  PR-LncRNA  expression and  SOX1 ,  SOX2  and  SOX9  stem cell factors in human glioma biopsies and in glioma cells  in vitro . Moreover, knock-down of  SOX  activity abolished the effect of  PR-LncRNA  silencing in glioma cell activity. In conclusion, our results demonstrate that the expression and function of  PR-LncRNA s are significantly altered in gliomagenesis and that their activity is mediated by SOX factors. These results may provide important insights into the mechanisms responsible for glioblastoma pathogenesis.

PR-LncRNA signature regulates glioma cell activity through expression of SOX factors