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A simple protocol to overcome the problematic trifluoromethylation of carbonyl compounds by the potent greenhouse gas “HFC-23, fluoroform” with a potassium base is described. Simply the use of glymes as a solvent or an additive dramatically improves the yields of this transformation. Experimental results and DFT calculations suggest that the beneficial effect deals with glyme coordination to the K +  to produce [K(polyether) n ] +  whose diminished Lewis acidity renders the reactive anionoid CF 3  counterion species more ‘naked’, thereby slowing down its undesirable decomposition to CF 2  and F −  and simultaneously increasing its reactivity towards the organic substrate.

scientific reports

Direct nucleophilic trifluoromethylation of carbonyl compounds by potent greenhouse gas, fluoroform: Improving the reactivity of anionoid trifluoromethyl species in glymes