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Iodine-131 ( 131 I) is an essential and widely used radioisotope in thyroid diseases and animal experiments. Planar imaging has been considered the most popular method for  131 I thyroid uptake radioactive activity quantification. The ROI defining section is essential and can affect the accuracy of quantitative results. However, a consistent method has not been proposed. In this study, a UC-ROI defining method based on ULWL setting and colour display grade was applied. Three steps were performed: image acquisition of five standard activity models and obtaining the exact value that the counts per radioactive activity contributes to the ROI; image acquisition of 20 rat thyroids and obtaining the counts of the ROI (thyroid); and calculating the rat thyroid radioactive activity and comparing these values with the true values. The accuracy of quantification activity of  131 I in rat thyroid reached 2.62% ± 0.41%. The mean quantification within 5% could be achieved in 19 of 20 rat thyroids. No significant difference existed between calculated thyroid  131 I activity and true values with a paired matched-test (t = −0.384, P = 0.706 > 0.05). The results indicated that with the UC-ROI defining method, more accurate thyroid uptake  131 I radioactive activity quantification by SPECT planar imaging can be achieved  in vivo  rat study.

Quantification of radioactivity by planar gamma-camera images, a promoted method of absorbed dose in the thyroid after iodine-131 treatment