English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Streptococcus mutans  and  Streptococcus sobrinus  are the main causative agents of human dental caries. Current strategies for treating caries are costly and do not completely eradicate them completely. Passive immunization using nonhuman antibodies against Streptococcal surface antigens has shown success in human trials, however they often invoke immune reactions. We used phage display to generate human antigen-binding fragments (Fabs) against  S .  mutans  and  S .  sobrinus . These Fabs were readily expressed in  E .  coli  and bound to the surface  S .  mutans  and  S .  sobrinus . Fabs inhibited sucrose-induced  S .  mutans  and  S .  sobrinus  biofilm formation  in vitro  and a combination of  S .  mutans  and  S .  sobrinus  Fabs prevented dental caries formation in a rat caries model. These results demonstrated that  S .  mutans  and  S .  sobrinus  Fabs could be used in passive immunization strategies to prevent dental caries. In the future, this strategy may be applied towards a caries therapy, whereby Fabs are topically applied to the tooth surface.

Synthetic antigen-binding fragments (Fabs) against S. mutans and S. sobrinus inhibit caries formation