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In order to facilitate/expedite the production of effective and affordable snake antivenoms, a novel  in vitro  potency assay was previously developed. The assay is based on an antiserum’s ability to bind to postsynaptic neurotoxin (PSNT) and thereby inhibit the PSNT binding to the nicotinic acetylcholine receptor (nAChR). The assay was shown to work well with antiserum against Thai  Naja kaouthia  which produces predominantly the lethal PSNTs. In this work, the assay is demonstrated to work well with antiserum/antivenom against  Bungarus candidus  (BC), which also produces lethal presynaptic neurotoxins, as well as antivenom against Sri Lankan  Naja naja  (NN), which produces an abundance of cytotoxins. The  in vitro  and  in vivo  median effective ratios (ER 50 s) for various batches of antisera against BC showed a correlation ( R  2 ) of 0.8922 ( p  < 0.001) while the corresponding value for the anti-NN antivenom was  R  2  = 0.7898 ( p  < 0.01). These results, together with the known toxin profiles of various genera of elapids, suggest that this  in vitro  assay could be used with antisera against other species of  Bungarus  and  Naja  and possibly other neurotoxic snake venoms worldwide. The assay should significantly save numerous lives of mice and accelerate production of life-saving antivenoms.

An in vitro potency assay using nicotinic acetylcholine receptor binding works well with antivenoms against Bungarus candidus and Naja naja