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New ruthenium(II) complexes were synthesised and characterized by various spectro analytical techniques. The structure of the complexes  3  and  4  has been confirmed by X-ray crystallography. The complexes were subjected to study their anti-oxidant profile and were exhibited significantly greater  in vitro  DPPH radical scavenging activity than vitamin C. We found that complexes  1–4  confered tolerance to oxidative stress and extend the mean lifespan of  mev-1  mutant worms and wild-type  Caenorhabditis elegans . Further, mechanistic study and reporter gene expression analysis revealed that Ru( ƞ  6  -p -cymene) complexes maintained the intracellular redox status and offers stress resistance through activating JNK-1/DAF-16 signaling axis and possibly by other antioxidant response pathway. Notably, complex  3  and  4  ameliorates the polyQ (a Huntington’s disease associated protein) mediated proteotoxicity and related behavioural deficits in Huntington’s disease models of  C. elegans . From these observations, we hope that new Ru( ƞ  6  -p -cymene) complexes could be further considered as a potential drug to retard aging and age-related neurodegenerative diseases.

scientific reports

Organoruthenium(II) Complexes Ameliorates Oxidative Stress and Impedes the Age Associated Deterioration in Caenorhabditis elegans through JNK-1/DAF-16 Signalling