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Trichuris trichiura  (whipworm) is one of the four major soil-transmitted helminth infections of man, affecting an estimated 465 million people worldwide. An effective vaccine that induces long-lasting protective immunity against  T .  trichiura  would alleviate the morbidity associated with this intestinal-dwelling parasite, however the lack of known host protective antigens has hindered vaccine development. Here, we show that vaccination with ES products stimulates long-lasting protection against chronic infection in male C57BL/6 mice. We also provide a framework for the identification of immunogenic proteins within  T .  muris  ES, and identify eleven candidates with direct homologues in  T .  trichiura  that warrant further study. Given the extensive homology between  T .  muris  and  T .  trichiura  at both the genomic and transcriptomic levels, this work has the potential to advance vaccine design for  T .  trichiura .

Vaccination Against Whipworm: Identification of Potential Immunogenic Proteins in Trichuris muris Excretory/Secretory Material