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Atrial fibrillation (AF) is the most common arrhythmia. In 2014, two new meta-GWAS identified 5 AF loci, including the  NEURL  locus,  GJA1  locus,  CAND2  locus, and  TBX5  locus in the European ancestry populations and the  NEURL  locus and  CUX2  locus in a Japanese population. The  TBX5  locus for AF was reported by us in 2013 in the Chinese population. Here we assessed the association between AF and SNPs in the  NEURL ,  GJA1 ,  CAND2  and  CUX2  loci in the Chinese Han population. We carried out a large case-control association study with 1,164 AF patients and 1,460 controls. Significant allelic and genotypic associations were identified between  NEURL  variant rs6584555 and  GJA1  variant rs13216675 and AF. Significant genotypic association was found between  CUX2  SNP rs6490029 and AF. No association was found between  CAND2  variant rs4642101 and AF, which may be due to an insufficient power of the sample size for rs4642101. Together with our previous findings, seven of fifteen AF loci (<50%) identified by GWAS in the European ancestry populations conferred susceptibility to AF in the Chinese population, and explained approximately 14.5% of AF heritability. On the other hand, two AF loci identified in the Japanese population were both replicated in the Chinese population.

Genomic Variants in NEURL, GJA1 and CUX2 Significantly Increase Genetic Susceptibility to Atrial Fibrillation