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The roles of long non-coding RNAs (lncRNAs), a class of long non-protein-coding RNAs, in the tumorigenesis of ovarian epithelial cells remain unknown. In this study, we discovered that the expression of  long intergenic non-coding RNA 1088  ( LINC01088)  was clearly reduced in benign epithelial ovarian tumor tissues compared to matched normal ovarian tissues. This was shown by global cDNA gene chip scanning and real-time qPCR, and validated in 42 clinical specimens. Furthermore, we found that  LINC01088  inhibited the growth of ovarian cancer xenografts in nude mice. Correlation analysis between  LINC01088  and mircoRNAs (miRNAs) conducted using primary clinical samples and RNA co-precipitation experiments revealed that  miR-24-1- 5 p  was one of the targets of  LINC01088 . Overexpression of  miR-24-1- 5 p  facilitated cell proliferation both  in vitro  and  in vivo , however,  LINC01088  could partially reverse the cell proliferation induced by  miR-24-1- 5 p . Finally, we demonstrated that  p21 activated kinase 4 (PAK4)  was one of the downstream key targets of  miR-24-1- 5 p  by luciferase reporter assay and Western blotting; and our results showed a remarkable decrease in cell proliferation after overexpression of PAK4. We conclude that  LINC01088  might function as a tumor suppressor, inhibiting the tumorigenesis of ovarian epithelial cells through  LINC01088 /  miR-24-1-5p /  PAK4  axis.

LINC01088 inhibits tumorigenesis of ovarian epithelial cells by targeting miR-24-1-5p