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Salmonella  infections in newly hatched chicks result in enteric and systemic diseases with a high mortality. Probiotics can improve the health of a host. The purpose of the present study was to investigate the effect of  Lactobacillus plantarum  LTC-113 on the gut permeability in the presence or absence of  Salmonella  ( Salmonella  Typhimurium) infection. Newly hatched chicks were randomly allocated to 4 treatments (i) NC (negative control); (ii) LAC (the  L. plantarum  LTC-113-treated group); (iii) SAL (the  Salmonella -infected group), and (iv) LAC + SAL (the  L. plantarum  LTC-113-treated and  Salmonella -infected group). Compared with the NC group, the intestinal permeability and claudin-2 (CLDN-2) were significantly increased, while mRNA levels of zonula occludens-1 (ZO-1) and claudin-5 (CLDN-5) were significantly decreased in the SAL group. However, these changes were eliminated in the LAC + SAL group. Additionally, numbers of  Salmonella  in liver, spleen and ceca were significantly reduced in the LAC + SAL group compared with the SAL group. Moreover,  L. plantarum  LTC-113 prevented the increase of inflammatory meditators myeloperoxidase (MPO), LITAF, IL-1β, IL-6 and inflammation scores induced by  Salmonella . These findings indicate that  L. plantarum  LTC-113 can protect hosts from  Salmonella  induced intestinal barrier disruption by regulating expression of tight junction genes and inflammatory meditators and decreasing  Salmonella  colonization.

Lactobacillus plantarum Restores Intestinal Permeability Disrupted by Salmonella Infection in Newly-hatched Chicks