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The aim of this work was to study the genetic basis of the backfat expression of lipid-related genes associated with meat quality traits in pigs. We performed a genome-wide association study with the backfat gene expression measured in 44 genes by qPCR and the  PorcineSNP60 BeadChip  genotypes in 115 Iberian x Landrace backcross animals. A total of 193 expression-associated SNPs located in 19 chromosomal regions were associated with expression levels of  ACSM5 ,  ELOVL6 ,  FABP4 ,  FADS2 , and  SLC27A4  genes. Three expression quantitative trail loci (eQTLs) corresponding to  ACSM5 ,  FABP4 , and  FADS2  were classified as  cis -acting eQTLs, whereas the remaining 16 eQTLs have  trans -regulatory effects. Remarkably, a SNP in the  ACSM5  promoter region and a SNP in the 3′UTR region of  FABP4  were the most associated polymorphisms with the  ACSM5  and  FABP4  expression levels, respectively. Moreover, relevant lipid-related genes mapped in the  trans -eQTLs regions associated with the  ACSM5 ,  FABP4 ,  FADS2 , and  SLC27A4  genes. Interestingly, a  trans -eQTL hotspot on SSC13 regulating the gene expression of  ELOVL6 ,  ELOLV5 , and  SCD , three important genes implicated in the elongation and desaturation of fatty acids, was identified. These findings provide new data to further understand the functional regulatory mechanisms implicated in the variation of fatty acid composition in pigs.

Expression analysis of candidate genes for fatty acid composition in adipose tissue and identification of regulatory regions