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Nine new guaianes (graphostromanes A – I,  1  –  9 ) were isolated from the deep-sea-derived fungus  Graphostroma  sp. MCCC 3A00421, along with four known ones ( 10  –  13 ). The relative configurations were established mainly by detailed analysis of the NMR and HRESIMS data, while the absolute configurations were assigned using the X-ray crystallography and modified Mosher’s method. All isolates were evaluated for their inhibitory effects against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages. Graphostromanes F ( 6 ) showed remarkable inhibitory effect with an IC 50  value of 14.2  μ M, which was even stronger than that of aminoguanidine, a positive control with an IC 50  value of 23.4  μ M.

New anti-inflammatory guaianes from the Atlantic hydrotherm-derived fungus Graphostroma sp. MCCC 3A00421