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Similar to many diurnal animals,  Drosophila melanogaster  exhibits a mid-day siesta that is more robust as temperature increases, an adaptive response that aims to minimize the deleterious effects from exposure to heat. This temperature-dependent plasticity in mid-day sleep levels is partly based on the thermal sensitive splicing of an intron in the 3′ untranslated region (UTR) of the circadian clock gene termed  period  ( per ). In this study, we evaluated a possible role for the serine/arginine-rich (SR) splicing factors in the regulation of dmpi8 splicing efficiency and mid-day siesta. Using a  Drosophila  cell culture assay we show that B52/SRp55 increases dmpi8 splicing efficiency, whereas other SR proteins have little to no effect. The magnitude of the stimulatory effect of B52 on dmpi8 splicing efficiency is modulated by natural variation in single nucleotide polymorphisms (SNPs) in the  per  3′ UTR that correlate with B52 binding levels. Down-regulating  B52  expression in clock neurons increases mid-day siesta and reduces dmpi8 splicing efficiency. Our results establish a novel role for SR proteins in sleep and suggest that polymorphisms in the  per  3′ UTR contribute to natural variation in sleep behavior by modulating the binding efficiencies of SR proteins.

The SR protein B52/SRp55 regulates splicing of the period thermosensitive intron and mid-day siesta in Drosophila