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There is a need to clarify relationships within the actinobacterial genus  Micromonospora , the type genus of the family  Micromonosporaceae , given its biotechnological and ecological importance. Here, draft genomes of 40  Micromonospora  type strains and two non-type strains are made available through the  Genomic Encyclopedia of Bacteria and Archaea  project and used to generate a phylogenomic tree which showed they could be assigned to well supported phyletic lines that were not evident in corresponding trees based on single and concatenated sequences of conserved genes. DNA G+C ratios derived from genome sequences showed that corresponding data from species descriptions were imprecise. Emended descriptions include precise base composition data and approximate genome sizes of the type strains. antiSMASH analyses of the draft genomes show that micromonosporae have a previously unrealised potential to synthesize novel specialized metabolites. Close to one thousand biosynthetic gene clusters were detected, including NRPS, PKS, terpenes and siderophores clusters that were discontinuously distributed thereby opening up the prospect of prioritising gifted strains for natural product discovery. The distribution of key stress related genes provide an insight into how micromonosporae adapt to key environmental variables. Genes associated with plant interactions highlight the potential use of micromonosporae in agriculture and biotechnology.

Genome-based classification of micromonosporae with a focus on their biotechnological and ecological potential