English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Persistent and stable respiratory activity across behavioral states is key to homeostasis. Extrasynaptic δ-subunit containing GABA A  receptors (δGABA A Rs) mediate tonic inhibition and regulate network activity. However, the influence of δGABA A Rs on respiratory rhythm and motor outputs is unknown. We manipulated extra-synaptic GABA A  receptor function in the preBötzinger Complex (preBötC), a site central to the generation of inspiratory motor activity in mammals. Activation of preBötC δGABA A Rs in anesthetized rats and wild-type mice decreased breathing rate. In δGABA A R knockout ( Gabrd   −/− ) mice, however, δGABA A Rs activation had no effect on breathing rate. We then found that during active wakefulness associated with behaviors and movements, diaphragm activation was higher in the  Gabrd   −/−  compared to wild-type mice, but not in other states. These findings identify that δGABA A Rs modulate the respiratory network, which is critical to understand how δGABA A Rs change breathing in pathological conditions affecting extra-synaptic GABA A  receptor function such as exposure to anesthetics and neurosteroids.

δ-Subunit Containing GABAA Receptors Modulate Respiratory Networks