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Long noncoding RNAs (lncRNAs) have been shown to play critical roles in cancer.  lncTCF7  (gene symbol: WSPAR) has been reported to maintain stemness in hepatocellular carcinoma (HCC) stem cells. However, little is known about the role of  lncTCF7  in glioma. The aim of this study was to identify the role of  lncTCF7  in the pathogenesis of glioma. We analysed the relationship of  lncTCF7  expression with clinicopathological characteristics in glioma patients. Our results showed that  lncTCF7  expression was increased in glioma tissues compared with that in normal brain tissues (P < 0.001). Moreover,  lncTCF7  was significantly associated with WHO grade (I–II vs. III–IV; P = 0.006) and tumour size (<3 cm vs. T ≥ 3 cm; P = 0.025). Meanwhile, patients with high  lncTCF7  expression levels exhibited markedly worse overall survival prognoses (P < 0.01). Loss of function assays revealed that knockdown of  lncTCF7  significantly inhibited glioma cell migration, proliferation and tumorigenicity  in vitro  and  in vivo . Furthermore, we found that hypoxia induced  lncTCF7  expression in an autocrine manner through IL-6 in glioma. In conclusion,  lncTCF7  may play a vital role in glioma progression and serves as a potential prognostic biomarker in glioma patients, providing new targets for glioma therapy.

lncTCF7 is a negative prognostic factor, and knockdown of lncTCF7 inhibits migration, proliferation and tumorigenicity in glioma