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The small intestine plays an essential role in the health and well-being of animals. Previous studies have shown that  Lactobacillus  has a protective effect on intestinal morphology, intestinal epithelium integrity and appropriate maturation of gut-associated tissues. Here, gene expression in jejunum tissue of weaned piglets was investigated by RNA-seq analysis after administration of sterile saline,  Lactobacillus reuteri , or an antibiotic (chlortetracycline). In total, 401 and 293 genes were significantly regulated by chlortetracycline and  L. reuteri , respectively, compared with control treatment. Notably, the  HP ,  NOX1  and  GPX2  genes were significantly up-regulated in the  L. reuteri  group compared with control, which is related to the antioxidant ability of this strain. In addition, the expression of genes related to arachidonic acid metabolism and linoleic acid metabolism enriched after treatment with  L. reuteri . The fatty acid composition in the jejunum and colon was examined by GC-MS analysis and suggested that the MUFA C18:1n9c, and PUFAs C18:2n6c and C20:4n6 were increased in the  L. reuteri  group, verifying the GO enrichment and KEGG pathway analyses of the RNA-seq results. The results contribute to our understanding of the probiotic activity of this strain and its application in pig production.

Gene expression profile changes in the jejunum of weaned piglets after oral administration of Lactobacillus or an antibiotic