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Mice exposed to chronic subordinate colony housing (CSC) stress show glucocorticoid (GC) resistance of  in vitro  lipopolysaccharide (LPS)-stimulated splenocytes, increased anxiety and colitis. Similar effects were reported in wounded mice exposed to social disruption (SDR). Here we show that CSC exposure induced GC resistance in isolated and  in  vitro LPS-stimulated, but not unstimulated, splenocytes, and these effects were absent when CD11b +  splenocytes were depleted. Moreover, re-active coping behaviour during CSC correlated with the attacks and bites received by the resident, which in turn highly correlated with the dimension of splenic GC resistance, as with basal and LPS-induced  in vitro  splenocyte viability. Importantly, social stress promoted spleen cell activation, independent of bite wounds or CD11b + /CD11b −  cell phenotype, whereas GC resistance was dependent on both bite wounds and the presence of CD11b +  cells. Together, our findings indicate that the mechanisms underlying splenic immune activation and GC resistance following social stress in male mice are paradigm independent and, to a large extent, dependent on wounding, which, in turn, is associated with a re-active coping style.

Splenic glucocorticoid resistance following psychosocial stress requires physical injury