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We performed a systematic identification of microRNAs (miRNAs) involved in the control of innate immunity. We identified 7 novel miRNA mutants with altered survival, colony forming in the body, and expression pattern of putative antimicrobial genes after  Pseudomonas aeruginosa  infection. Loss-of-function mutation of  mir-45, mir-75, mir-246, mir-256 , or  mir-355  induced resistance to  P. aeruginosa  infection, whereas loss-of-function mutation of  mir-63  or  mir-360  induced susceptibility to  P. aeruginosa  infection. DAF-2 in the insulin signaling pathway acted as a target for intestinal  mir-355  to regulate innate immunity.  mir-355  functioned as an important link between p38 MAPK signaling pathway and insulin signaling pathway in the regulation of innate immunity. Our results provide an important molecular basis for further elucidation of the functions of various miRNAs in the regulation of innate immunity.

mir-355 Functions as An Important Link between p38 MAPK Signaling and Insulin Signaling in the Regulation of Innate Immunity