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As one of the important gas signal molecules, hydrogen sulfide (H 2 S) is associated with many important physiological processes in living organisms. Organelles, especially endoplasmic reticulum (ER), play a crucial role in the cell metabolism. Accordingly, the detection of H 2 S in the ER is of high interest. Toward this goal, we have described the development of the first ER-targeted fluorescent H 2 S probe ( Na-H    2    S-ER ). The new probe exhibited favorable features, such as a large turn-on fluorescence signal (45-fold fluorescence enhancement), high sensitivity and selectivity. The probe was successfully employed for imaging exogenous and endogenous H 2 S in the living HeLa cells. Significantly, the new probe  Na-H    2    S-ER  was employed to visualize H 2 S in the ER of living cells for the first time. In addition, the probe was also successfully used for imaging H 2 S in the living tissues up to a depth of 100 μm and in the living zebrafish.

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A turn-on endoplasmic reticulum-targeted two-photon fluorescent probe for hydrogen sulfide and bio-imaging applications in living cells, tissues, and zebrafish