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The 1,3-dipolar cycloaddition of active azomethine ylide, which were generated  in situ  from addition reaction of α-amino acids with dialkyl acetylenedicarboxylates, with 2-arylidene-1,3-indanediones showed versatile regioselectivity and diastereoselectivity. The reaction of sarcosine and glycine afforded one kind of functionalized spiro[indene-2,3′-pyrrolidines]. The other primary α-amino acids such as alanine, phenylalanine and leucine gave another kind of regioisomeric spiro[indene-2,3′-pyrrolidines]. The cyclic α-amino acids resulted in the corresponding spiro[indene-2,2′-pyrrolizines] and [indene-2,6’-pyrrolo[1,2-c]thiazoles].

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Regioselectivity and diastereoselectivity of three-component reaction of α-amino acid, dialkyl acetylenedicarboxylates and 2-arylidene-1,3-indanediones