English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Ten antifouling 14-membered resorcylic acid lactones  1 – 10  were isolated previously with low or trace natural abundance from the zoanthid-derived  Cochliobolus lunatus  fungus. Further optimization of fermentation conditions led to the isolation of two major natural compounds  7  and  8  with multi-gram quantities. By one or two steps, we semisynthesized the six trace natural compounds  1 – 6  and a series of derivatives  11 – 27  of compounds  7  and  8  with high yields (65–95%). Compounds  11 – 13  showed strong antiplasmodial activity against  Plasmodium falciparum  with IC 50  values of 1.84, 8.36, and 6.95  μ M, respectively. Very importantly,  11  and  12  were non-toxic with very safety and high therapeutic indices (CC 50 /IC 50  > 180), and thus representing potential promising leads for antiplasmodial drug discovery. Furthermore,  11  was the only compound showed obvious antileishmanial activity against  Leishmania donovani  with an IC 50  value of 9.22  μ M. Compounds  11  and  12  showed the values of IC 50  at 11.9 and 17.2  μ M against neglected Chagas’ disease causing  Trypanosoma cruzi , respectively.

Discovery, Semisynthesis, Antiparasitic and Cytotoxic Evaluation of 14-Membered Resorcylic Acid Lactones and Their Derivatives