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Venus kinase receptors (VKR) are a subfamily of invertebrate receptor tyrosine kinases, which have only recently been discovered. They contain an intracellular tyrosine kinase domain and an extracellular Venus FlyTrap domain. VKRs have been functionally and pharmacologically characterized in only two invertebrate species, namely the human parasite  Schistosoma mansoni  and the mosquito  Aedes aegypti , where they play a crucial role in oogenesis. Here, we report the characterization of a VKR in the desert locust,  Schistocerca gregaria . We performed an in-depth profiling study of the  SgVKR  transcript levels in different tissues throughout the female adult stage. Using the RNA interference technique, the possible role of  SgVKR  was investigated.  SgVKR  knockdown had significant effects on ovarian ecdysteroid levels and on the size of oocytes during the vitellogenic stage.  Sg VKR is probably involved in the complex cross-talk between several important pathways regulating female reproductive physiology. Contrary to  A. aegypti  and  S. mansoni , we cannot conclude that this receptor is essential for reproduction, since silencing  SgVKR  did not affect fecundity or fertility. Considering the evolutionary distance between  A. aegypti  and  S. gregaria , as well as the differences in regulation of their female reproductive physiology, this article constitutes a valuable asset in better understanding VKRs.

Role of the venus kinase receptor in the female reproductive physiology of the desert locust, Schistocerca gregaria