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Staphylococcus capitis  TE8 was isolated from skin surface of a healthy human foot, and exhibited a strong antibacterial activity against Gram-positive bacteria, including  Staphylococcus aureus . Whole genome sequence of  S. capitis  TE8 was obtained by shotgun and paired-end pyrosequencing with a coverage of 109-fold. The draft genome contains 2,516,639 bp in 8 scaffolds with 209 total contigs. The genome contains 2319 protein coding sequences, 58 tRNA and 3 rRNA. Genome sequence analysis revealed 4 distinct gene loci with the ability to encode antimicrobial peptides: (i) an epidermicin gene cluster; (ii) a gallidermin gene cluster; (iii) a gene cluster encoding six phenol soluble modulin (PSM) β-type peptides (PSMβ1-β6) and (iv) an additional gene that belonged to PSMβ family and encoded a 44 residues long peptide, HTP2388. Synthetic peptides with sequence identical to seven PSMβ-like peptides i.e. PSMβ1-β6 and peptide HTP2388 showed antibacterial activity. Genome sequence also revealed genes for adhesins, intracellular adhesins, osmoadaptation, oxidative and acid stress tolerance possibly responsible for initial attachment, colonization and survival of  S. capitis  TE8 on human skin. Comparative genome analysis revealed presence of a gamut of genes in  S. capitis  strains in comparison to  Staphylococcus epidermidis  and  Staphylococcus caprae  indicating towards their possible role in better adaptation and survival on human skin.

Genome Analysis of Staphylococcus capitis TE8 Reveals Repertoire of Antimicrobial Peptides and Adaptation Strategies for Growth on Human Skin