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The bactericidal/permeability-increasing (BPI) fold-containing (BPIF) superfamily of genes expressed in the brain are purportedly involved in modulating brain function in response to stress, such as inflammation. Kisspeptin, encoded by  kiss , is affected by inflammation in the brain; therefore, BPIF family genes might be involved in the modulation of kisspeptin in the brain. In this study, we investigated the expression of BPIF family C, like ( bpifcl ) in zebrafish brain and its involvement in  kiss2  regulation. The identified, full-length sequence of a  bpifcl  isoform expressed in the zebrafish brain contained the BPI fold shared by BPIF family members.  bpifcl  mRNA expression in female zebrafish brains was significantly higher than that in males. Exposure of female zebrafish to 11-ketotestosterone decreased  bpifcl  and  kiss2  mRNA expression.  bpifcl  knockdown by  bpifcl -specific small interfering RNA administration to female zebrafish brain decreased  kiss2  mRNA expression.  bpifcl  expression was widely distributed in the brain, including in the dorsal zone of the periventricular hypothalamus (Hd). Furthermore,  bpifcl  was also expressed in KISS2 neurons in the Hd. These results suggest that the Bpifcl modulates  kiss2  mRNA expression under the influence of testosterone in the Hd of female zebrafish.

Bpifcl modulates kiss2 expression under the influence of 11-ketotestosterone in female zebrafish