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Adipogenesis plays an important role in the regulation of whole-body energy homeostasis and is inextricably related to obesity. Several studies have highlighted the relevance of microRNAs in adipocyte differentiation, but the contributions of long non-coding RNAs (lncRNAs) are still largely uncharacterized. Here, we determined that lncRNA  MIR31HG  is related to adipocyte lineage commitment. We demonstrated that knockdown of  MIR31HG  inhibited adipocyte differentiation, whereas overexpression of  MIR31HG  promoted adipogenesis  in vitro  and  in vivo . Furthermore, inhibition of  MIR31HG  reduced the enrichment of active histone markers, histone H3 lysine 4 trimethylation (H3K4me3) and acetylation (AcH3), in the promoter of the adipogenic-related gene, fatty acid binding protein 4 ( FABP4 ), leading to suppression of its expression and adipogenesis. These results provide new insights into the molecular mechanisms of  MIR31HG  in terms of adipogenesis and may have implications for obesity and associated disorders.

Knockdown of lncRNA MIR31HG inhibits adipocyte differentiation of human adipose-derived stem cells via histone modification of FABP4