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The attachment of spindle fibres to the kinetochore is an important process that ensures successful completion of the cell division. The Ca 2+  concentration increases during the mitotic phase and contributes microtubule stability. However, its role in the spindle organisation in mitotic cells remains controversial. Here, we investigated the role of Ca 2+  on kinetochore fibres in living cells. We found that depletion of Ca 2+  during mitosis reduced kinetochore fibre stability. Reduction of kinetochore fibre stability was not due to direct inhibition of microtubule polymerisation by Ca 2+ -depletion but due to elimination of one dynamic component of kinetochore, CENP-F from the kinetochore. This compromised the attachment of kinetochore fibres to the kinetochore which possibly causes mitotic defects induced by the depletion of Ca 2+ .

Calcium depletion destabilises kinetochore fibres by the removal of CENP-F from the kinetochore