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We compared gene expression in low and high-grade intraepithelial dysplastic polyps from pigs carrying an  APC    1311   truncating mutation orthologous to human  APC    1309  , analysing whole samples and microdissected dysplastic epithelium. Gene set enrichment analysis revealed differential expression of gene sets similar to human normal mucosa versus T1 stage polyps. Transcriptome analysis of whole samples revealed many differentially-expressed genes reflecting immune infiltration. Analysis of microdissected dysplastic epithelium was markedly different and showed increased expression in high-grade intraepithelial neoplasia of several genes known to be involved in human CRC; and revealed possible new roles for  GBP6  and  PLXND1 . The pig model thus facilitates analysis of CRC pathogenesis.

Porcine familial adenomatous polyposis model enables systematic analysis of early events in adenoma progression