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Antibiotic-resistant  Acinetobacter baumannii  is associated with nosocomial infections worldwide. Here, we used clinically isolated  A. baumannii  strains as models to demonstrate whether antibiotic resistance is correlated with an increased susceptibility to bacteriophages. In this study, 24 active phages capable of infecting  A. baumannii  were isolated from various environments, and the susceptibilities of both antibiotic-sensitive and antibiotic-resistant strains of  A. baumannii  to different phages were compared. In our study, a total of 403 clinically isolated  A. baumannii  strains were identified. On average, the phage infection percentage of the antibiotic-resistant  A. baumannii  strains was 84% (from 81–86%), whereas the infection percentage in the antibiotic-sensitive  A. baumannii  strains was only 56.5% (from 49–64%). In addition, the risk of phage infection for  A. baumannii  was significantly increased in the strains that were resistant to at least four antibiotics and exhibited a dose-dependent response ( p -trend < 0.0001). Among all of the  A. baumannii  isolates, 75.6% were phage typeable. The results of phage typing might also reveal the antibiotic-resistant profiles of clinical  A. baumannii  strains. In conclusion, phage susceptibility represents an evolutionary trade-off in  A. baumannii  strains that show adaptations for antibiotic resistance, particularly in medical environments that have high antibiotic use.

Clinical Antibiotic-resistant Acinetobacter baumannii Strains with Higher Susceptibility to Environmental Phages than Antibiotic-sensitive Strains