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Emerging evidence supports that stem cells are regulated by both intrinsic and extrinsic mechanisms. However, factors that determine the fate of stem cells remain incompletely understood. The  Drosophila  testis provides an exclusive powerful model in searching for potential important regulatory factors and their underlying mechanisms for controlling the fate of germline stem cells (GSCs). In this study, we have found that  Drosophila gilgamesh  ( gish ), which encodes a homologue of human CK1-γ (casein kinase 1-gamma), is required intrinsically for GSC maintenance. Our genetic analyses indicate  gish  is not required for Dpp/Gbb signaling silencing of  bam  and is dispensable for Dpp/Gbb signaling-dependent Dad expression. Finally, we show that overexpression of  gish  fail to dramatically increase the number of GSCs. These findings demonstrate that  gish  controls the fate of GSCs in  Drosophila  testis by a novel Dpp/Gbb signaling-independent pathway.

Gilgamesh is required for the maintenance of germline stem cells in Drosophila testis