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Previous studies from European and East Asian cohorts reported conflicting results over whether and how the frequencies of the three common alleles,  ε 2,  ε 3 and  ε 4, of the apolioprotein E gene  (APOE) , in long-lived individuals differ from those in younger age groups. This study was the first to analyse these frequencies of long-lived individuals from central China. Genotyping of  APOE  alleles and genotypes was carried out in 70 long-lived individuals and 204 younger controls. No difference in the frequency of any  APOE  allele or genotype was found between the long-lived participants and their younger controls, but the long-lived group seemed to have a higher  ε 4 frequency (15.71%) than the 24–50 and 51–75 age groups (10.2% and 11.32%, P > 0.05). Notably, when compared with two other Chinese studies, the central China long-lived group had a higher  ε 4 frequency than its southern and eastern China counterparts (15.71%  vs . 2.82% and 2.54%, P < 0.05). It is not clear to what extent population substructure or lifestyles contributed to these divergent findings. A clear understanding of the contribution of  APOE  polymorphisms to longevity in the Han Chinese population may be achieved only through large scale studies with participants from well-defined regional clusters.

APOE gene polymorphism in long-lived individuals from a central China population