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Ch HP1BP3, a chromatin complex-related protein known with dynamic features, was identified as a  ChHsp70  promoter-associated factor in  Crassostrea hongkongensis  by DNA-affinity purification and mass spectrometry analysis. Direct interaction between purified  Ch HP1BP3 and the  ChHsp70  promoter region was demonstrated using EMSA.  ChHp1bp3  depletion led to clear enhancements in  ChHsp70  mRNA expression in  C .  hongkongensis  hemocytes. However,  ChHp1bp3  overexpression in heterologous HEK293T cells correlated with fluctuations in  ChHsp70  transcription. Quantitative RT-PCR analysis showed that both  ChHsp70  and  ChHp1bp3  transcription were responsive to external physical/chemical stresses by heat, CdCl 2  and NP. This indicated a plausible correlation between  ChHsp70  and  ChHp1bp3  in the stress-induced genetic regulatory pathway. While, the distinctive  ChHp1bp3  expression patterns upon physical and chemical stresses suggest that the mechanisms that mediate  ChHp1bp3  induction might be stress-specific. This study discovered a novel role for HP1BP3 as a negative regulator in controlling  Hsp70  transcription in  C .  hongkongensis , and contributed to better understanding the complex regulatory mechanisms governing  Hsp70  transcription.

The novel transcriptional factor HP1BP3 negatively regulates Hsp70 transcription in Crassostrea hongkongensis