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Recent studies have implicated long non-coding RNA,  AC079767 . 4 , as a highly susceptible gene in tuberculosis. The aim of the study was to preliminarily explore the possible association of single nucleotide polymorphisms (SNPs) in  AC079767 . 4  gene with clinical phenotypes and TB susceptibility in Western Chinese Han population. The improved multiplex ligation detection reaction (iMLDR) method was employed to genotype 4 SNPs in  AC079767 . 4  in 554 tuberculosis patients and 561 healthy individuals. In subgroup analysis, only the C allele for rs12477677 was associated with the decreased susceptibility to pulmonary TB with a  p -value of 0.026, but  p -value was 0.103 after Bonferroni correction. In total samples, haplotype [ACAC], representing four  AC079767 . 4  variants, was found to slightly decrease TB risk ( p  = 0.045). Furthermore, patients with the CC genotype of rs12477677 were correlated with fewer occurrences of fever ( p  = 0.016), while patients carrying the T allele were associated with lower levels of ESR in the dominant model of rs1055229 ( p  = 0.021). For the first time, we reported the potential susceptibility and clinical traits of tuberculosis with lncRNA variants in the Western Han Chinese population. Our data indicate  AC079767 . 4  polymorphisms may potentially act as novel biomarkers for tuberculosis diagnostic and therapeutic purposes.

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Significance of genetic polymorphisms in long non-coding RNA AC079767.4 in tuberculosis susceptibility and clinical phenotype in Western Chinese Han population