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The Spitzer Space Telescope revolutionized studies of Active Galactic Nuclei(AGNs). Its combined sensitivity and mapping speed at mid-infrared wavelengthsrevealed a substantial population of highly-obscured AGNs. This populationimplies a higher radiative accretion efficiency, and thus possibly a higherspin for black holes than indicated by surveys in the optical and X-ray. Theunique mid-infrared spectrographic capability of Spitzer gave importantinsights into the distribution and nature of the dust surrounding AGNs,enabling the separation of AGN and starburst components, the detection ofsilicate features in emission from hot dust, and the identification of shockedgas associated with AGN activity. The sensitivity of Spitzer allowed almostcomplete identification of the host galaxies of samples of AGNs selected in theX-ray and radio. As we look forward to the James Webb Space Telescope, thelessons learned from Spitzer studies will inform observational programs withnew and upcoming infrared facilities.

Active Galactic Nuclei as seen by the Spitzer Space Telescope