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Developing organic field-effect transistor (OFET) biosensors for customizable detection of biomarkers for many diseases would provide a low-cost and convenient tool for both biological studies and clinical diagnosis. In this work, design principles of the OFET transducer for biosensors were derived to relate the signal-to-noise ratio ( SNR ) to the device-performance parameters. Steep subthreshold swing ( SS ), proper threshold voltage ( V  th ), good-enough bias-stress stability, and mechanical durability are shown to be the key prerequisites for realizing OFET bio-sensors of high transconductance efficiency ( g  m / I  D ) for large  SNR . Combining a low trap-density channel and a high- k /low- k  gate dielectric layer, low-temperature (&lt;100 °C) solution-processed flexible OFETs can meet the performance requirements to maximize the  g  m / I  D . An extended gate-structure OFET biosensor was further implemented for label-free detection of miR-21, achieving a detection limit below 10 pM with high selectivity at a low operation voltage (&lt;1 V).

Solution processed low power organic field-effect transistor bio-chemical sensor of high transconductance efficiency