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Bacteria display social behavior and establish cooperative or competitive interactions in the niches they occupy. The human skin is a densely populated environment where many bacterial species live. Thus, bacterial inhabitants are expected to find a balance in these interactions, which eventually defines their spatial distribution and the composition of our skin microbiota. Unraveling the physiological basis of the interactions between bacterial species in organized environments requires reductionist analyses using functionally relevant species. Here, we study the interaction between two members of our skin microbiota,  Bacillus subtilis  and  Staphylococcus epidermidis . We show that  B. subtilis  actively responds to the presence of  S. epidermidis  in its proximity by two strategies: antimicrobial production and development of a subpopulation with migratory response. The initial response of  B. subtilis  is production of chlorotetain, which degrades the  S. epidermidis  at the colony level. Next, a subpopulation of  B. subtilis  motile cells emerges. Remarkably this subpopulation slides towards the remaining  S. epidermidis  colony and engulfs it. A slow response back from  S. epidermidis  cells give origin to resistant cells that prevent both attacks from  B. subtilis . We hypothesized that this niche conquering and back-down response from  B. subtilis  and  S. epidermidis , respectively, which resembles other conflicts in nature as the ones observed in animals, may play a role in defining the presence of certain bacterial species in the specific microenvironments that these bacteria occupy on our skin.

Impact of spatial proximity on territoriality among human skin bacteria