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Photoredox catalysis has provided many approaches to C(sp 3 )–H functionalization that enable selective oxidation and C(sp 3 )–C bond formation via the intermediacy of a carbon-centered radical. While highly enabling, functionalization of the carbon-centered radical is largely mediated by electrophilic reagents. Notably, nucleophilic reagents represent an abundant and practical reagent class, motivating the interest in developing a general C(sp 3 )–H functionalization strategy with nucleophiles. Here we describe a strategy that transforms C(sp 3 )–H bonds into carbocations via sequential hydrogen atom transfer (HAT) and oxidative radical-polar crossover. The resulting carbocation is functionalized by a variety of nucleophiles—including halides, water, alcohols, thiols, an electron-rich arene, and an azide—to effect diverse bond formations. Mechanistic studies indicate that HAT is mediated by methyl radical—a previously unexplored HAT agent with differing polarity to many of those used in photoredox catalysis—enabling new site-selectivity for late-stage C(sp 3 )–H functionalization.

A general strategy for C(sp3)–H functionalization with nucleophiles using methyl radical as a hydrogen atom abstractor