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The nuclear lamina plays an important role in the regulation of chromatin organization and gene positioning in animals. CROWDED NUCLEI (CRWN) is a strong candidate for the plant nuclear lamina protein in  Arabidopsis thaliana  but its biological function was largely unknown. Here, we show that CRWNs localize at the nuclear lamina and build the meshwork structure. Fluorescence in situ hybridization and RNA-seq analyses revealed that CRWNs regulate chromatin distribution and gene expression. More than 2000 differentially expressed genes were identified in the  crwn1crwn4  double mutant. Copper-associated ( CA ) genes that form a gene cluster on chromosome 5 were among the downregulated genes in the double mutant exhibiting low tolerance to excess copper. Our analyses showed this low tolerance to copper was associated with the suppression of  CA  gene expression and that CRWN1 interacts with the  CA  gene locus, enabling the locus to localize at the nuclear lamina under excess copper conditions.

Subnuclear gene positioning through lamina association affects copper tolerance