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The  ter  region of the bacterial chromosome, where replication terminates, is the last to be segregated before cell division in  Escherichia coli . Delayed segregation is controlled by the MatP protein, which binds to specific sites ( matS ) within ter, and interacts with other proteins such as ZapB. Here, we investigate the role of MatP by combining short-time mobility analyses of the  ter  locus with biochemical approaches. We find that  ter  mobility is similar to that of a non  ter  locus, except when sister  ter  loci are paired after replication. This effect depends on MatP, the persistence of catenanes, and ZapB. We characterise MatP/DNA complexes and conclude that MatP binds DNA as a tetramer, but bridging  matS  sites in a DNA-rich environment remains infrequent. We propose that tetramerisation of MatP links  matS  sites with ZapB and/or with non-specific DNA to promote optimal pairing of sister  ter  regions until cell division.

Post-replicative pairing of sister ter regions in Escherichia coli involves multiple activities of MatP