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The selective transport of ions across cell membranes, controlled by membrane proteins, is critical for a living organism. DNA-based systems have emerged as promising artificial ion transporters. However, the development of stable and selective artificial ion transporters remains a formidable task. We herein delineate the construction of an artificial ionophore using a telomeric DNA G-quadruplex ( h-TELO ) and a lipophilic guanosine ( MG ).  MG  stabilizes  h-TELO  by non-covalent interactions and, along with the lipophilic side chain, promotes the insertion of  h-TELO  within the hydrophobic lipid membrane. Fluorescence assays, electrophysiology measurements and molecular dynamics simulations reveal that  MG / h-TELO  preferentially transports K + -ions in a stimuli-responsive manner. The preferential K + -ion transport is presumably due to conformational changes of the ionophore in response to different ions. Moreover, the ionophore transports K + -ions across CHO and K-562 cell membranes. This study may serve as a design principle to generate selective DNA-based artificial transporters for therapeutic applications.

Ionophore constructed from non-covalent assembly of a G-quadruplex and liponucleoside transports K+-ion across biological membranes